Since bone is a hierarchical multiscale material, homogenized responses are achieved at suf. Pdf mechanical properties and the hierarchical structure. The mechanical properties of bone tissue change during growth. It has also been attempted to correlate the mechanical properties with the microstructural. Applied sciences and engineering copyright 2020 3d printing. Our results reveal that tuning the interface structure, distribution, and phase stability to simultaneously activate multiple micromechanisms that resist crack propagation is key for the observed leap in mechanical response. Human cortical bones unique mechanical properties stem from its hierarchical structure, which spans some seven architectural levels from the individual collagen molecules and mineral platelets to the whole bone figure 1. Hierarchical structures of bone and bioinspired bone. Scale is of importance in discussing bone architecture as the structure is hierarchical and complex. Load cycling of metal components leads to fatigue and ultimately failure through the propagation of cracks. Bone has a complex hierarchical structure with the capability of selfregeneration. Bone structure has a decisive influence on its mechanical properties, and three types of cells that build it can be distinguished. Study of bone structure bone has a varied arrangement of material structures at many length scales which work in concert to perform diverse mechanical, biological and chemical functions. Comparison of the structure and mechanical properties of bovine femur bone and antler of the north american elk cervus elaphus canadensis p.
Carnelli a finite element model for directiondependent. At the lowest level, bone is a nanocomposite of collagen and mineral particles. Another example of a hierarchical structure in biology with excellent mechanical properties is that of cellulose, when organized into wood. Not surprisingly, bone provides a variety of mechanical, synthetic, and metabolic functions for. The results showed our 3dprinted hatcp scaffold with biomimetic hierarchical structure is biocompatible and has sufficient mechanical strength for surgery. Applied sciences and engineering copyright 2020 3d. Because of bone s hierarchical structure, its mechanical. Many biological tissues, such as wood and bone, are fiber composites with a hierarchical structure. The mechanical properties of compact bone provide resistance to tension. Correlations between structural and mechanical properties of human trabecular femur bone 39 therefore, the main purpose of the studies conducted is to determine the structural and mechanical properties of bone tissue, to search for correlations between them, and to attempt to describe such correlations by means of mathematical relationships. Processes free fulltext effect of bone morphogenic. In addition to possessing a hierarchical structure, bone is also anisotropic 9. Jiyu sun ab and bharat bhushan a a key laboratory of bionic engineering ministry of education, jilin university, changchun, 025, p. Analysis of trabecular bone as a hierarchical material iwona m.
This paper surveys the mechanical data that are available, with an emphasis on the relationship between the complex hierarchical structure of bone and its mechanical properties. Their exceptional mechanical properties are believed to be. The structure is loaded in a manner appropriate for its actual functiontension, compression, torsion, or bendingand its deformation is recorded as a function of the applied. The stiffness, strength and toughness properties 1 of bone develop from this multiscaled, hierarchical structure 14, which spans from nanometer to macroscopic dimensions fig. Mechanical principles of a selfsimilar hierarchical structure. Nov 26, 2019 human cortical bone contains two types of tissue. Depending upon species, age, and type of bone, bone cells represent up to 15 percent of the volume of bone. In order to understand the mechanical properties of bone material, it is important to understand the mechanical properties of its component phases, and the structural relationship between them at the various levels of hierarchical structural organization 1, 2, 3.
Revealing the remarkable nanostructure of human bone. Here we summarize some recent studies on an idealized selfsimilar hierarchical model of bone and bone like materials, and discuss mechanical principles of selfsimilar hierarchy, in particular to show how the characteristic length, aspect. The mechanical properties of bone are related to its hierarchical structure 2. The combination of the two materials in a hierarchical manner provides bone with mechanical properties that are superior to those of its individual components alone and we find that there are 12. Bone chemical composition and physical properties britannica. Bone bone chemical composition and physical properties. Biomimetic mechanisms of natural hierarchical materials a. Bonelike crack resistance in hierarchical metastable. Structure and mechanical properties of selected biological. Natural materials such as bone, shell, tendon and the attachment system of gecko exhibit multiscale hierarchical structures. The hierarchical structure of bone, from nano scale to the organ level, ultimately determines its mechanical strength and properties.
Contents 2 introduction the skeleton system types of the bones composition of bones functions of bones bone biomechanics 3. Water plays an important role in the biomineralization process and serves as a plasticizer, enhancing the toughness of bone. Bone nanostructure and its relevance for mechanical. However, the complexity of hierarchical structures, the requirement for mechanical properties, and the diversity of bone resident cells are the major challenges in constructing biomimetic bone tissue engineering. Pdf characterization of the effects of xray irradiation on. Model of hierarchical structure of collagen fibrils. Therefore, bone tissue engineering has since emerged to solve problems relating to criticalsized bone defects. To a great extent, differences between whole bones may be explained by the variance in their structure and mechanical function. The hierarchical structure of these materials is at the crux of this enhancement. Of the 25 types of collagen known, fibrilforming collagen is the main component in many tissues such as tendons, cartilage and bone to provide the structural framework and the strength of. This is especially true with respect to resistance to fracture where a.
In addition, the anisotropic structure of bone means that its mechanical properties must be considered in two orthogonal directions. Schematic drawing of the hierarchical make up of bone. At the nanoscale, bone is a composite with a quasiperiodic structure, consisting of carbonated hydroxyapatite ha crystals, which are embedded into collagen fibrils. Pdf mechanical properties and the hierarchical structure of bone. The ultrastructure of bone and its relevance to mechanical properties.
Microstructural features such as organized, layered organicinorganic structures and the presence of porous and. The quality of this material is crucial for the mechanical performance of bone as a whole. The bone is a hierarchically structured material with mechanical properties depending on its architecture at all scales. Local electronic structure and nanolevel hierarchical organization of bone tissue. In recent years hierarchical lattices have been made via 3d printing, rapid prototyping, and. School of mechanical engineer ing, georgia institute of technology, atlanta, ga 303320405, u. Fatigue of bone mechanical properties of whole bones. This approach is also used to characterize organicinorganic natural composites such as human bone, reindeer antler and nacre. For a greater understanding of the mechanical properties of bone as a whole, it is first necessary to determine the behaviour of each of the components in an individual way at its corresponding structural level, as well as its overall involvement. These materials have evolved to fulfill a variety of mechanical functions, for which the structures are presumably finetuned. Hierarchical structure and nanomechanics of collagen. They have highly complex structures, described in terms of up to 7 hierarchical levels of organization.
A novel model for porous scaffold to match the mechanical. Characterization of the effects of xray irradiation on. Summary we study trabecular bone as a hierarchical material with a highly complex and ra ndom structure. Analysis of trabecular bone as a hierarchical material iwona. On a macro scale, bone is an organ that performs well defined functions in the body, as well as a tissue composed of bone lamella forming a compact and cancellous bone. The remarkable mechanical properties of bone are due to its hierarchical structure which is optimized at all levels of hierarchy. Hierarchical cellular solids including honeycomb, foam, and lattice solids that are strong, lightweight. However, collagen fibrils in bone range from 20 to 40 nm in diameter, suggesting that there are 200 to 800 collagen molecules in the cross section of a fibril. We determined that a 30 wt% hatcp scaffold with biomimetic hierarchical structure exhibited superior mechanical properties and porosity. Study of microstructure and mechanical properties of human cortical bone s. Characterization of the effects of xray irradiation on the. Attempts to predict the mechanical properties of bone by applying composite rule of mixtures formulae have been only moderately successful, making it clear that an accurate. Its excellent mechanical properties are related to its hierarchical structures and precise organization of. Our results show that the unique mechanical properties of collagen microfibrils arise due to their hierarchical structure at the nanoscale, where key deformation mechanisms are straightening of twisted triplehelical molecules at small strains, followed by axial stretching and eventual molecular uncoiling.
Characterization of the effects of xray irradiation on the hierarchical structure and mechanical properties of human cortical bone holly d. Buehler, and paul hansma our bones are full of microscopic cracks, but the hierarchical character of the bones structure from molecular to macroscopic scalesmakes them remarkably resistant to fracture. Correlations between structural and mechanical properties. The nonliving intercellular material of bone consists of an organic component called collagen a fibrous protein arranged in long strands or. Finite element computations of mechanical properties of bone show that the model. In this section, we illustrate the anatomy and structure of bone tissue as the basis for studying tissue structure function and. The resulting hierarchical material has much better fatigue resistance properties than other iron alloys.
A comparative study of the mechanical properties of. Hierarchical structure along with materials such as hair, skin, and spider silk, bone belongs to a family of biological proteins that constitute critical building blocks of life. Improving the mechanical properties of irradiation sterilized bone allografts brianne burton master of applied science institute of biomaterials and biomedical engineering university of toronto 20 abstract bone allografts are used in orthopaedic reconstruction of defects resulting from trauma, bone cancer or infection. Structure and mechanics provides a cohesive introduction to collagenrich tissues, such as tendon, bone, cornea or arterials walls. Improving the mechanical properties of irradiation. However, in contrast to, the previous research hierarchy in this work is constructed by replacing every three edge vertex of a regular hexagonal honeycomb with a smaller hexagon. Mechanical properties of hierarchical honeycomb structures. Doitpoms tlp library structure of bone and implant. Introduction 3 bone tissue, or osseous tissue, a type of connective tissue used in forming bones. Local electronic structure and nanolevel hierarchical.
Collagen structure and mechanics peter fratzl springer. These variables mean that there is a range of measured properties for bone, and so values given in tables will always be an average, with quite a considerable spread possible in the data. Mechanical properties of collagen fibrils and elastic. Compositional and mechanical properties of growing cortical. Growing bone is not wellknown in terms of its intrinsic material properties. In the case of criticalsized defects, the regeneration capabilities of normal bones are severely impaired, thus causing nonunion healing of bones.
In order to understand the mechanical properties of bone material, it is. Cell proliferation was investigated in vitro, and the surgery was conducted in a nude mouse in vivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem cells. Every technique of assessing bone architecture or the properties of a given structure has its own resolution, and therefore a combination of techniques is required to reveal the material structures and properties at the many different length scales. Mechanical properties and the hierarchical structure of. Compositional and mechanical properties of growing cortical bone. Predicting accurately the behavior of a whole bone involves knowing the kinds of loads that are put on the bone, their directions and relative magnitudes, knowing the 3d structure of the bone in some detail, and finally knowing the mechanical properties of the material throughout the bone. Study of microstructure and mechanical properties of human. At the micron scale and above, bone tissue is a hierarchical composite fig. Characterization of nanostructural and nanomechanical. Chanda abstract the microstructure along with the micro mechanical properties of bone have been extensively observed in this study. Mechanical properties and the hierarchical structure of bone jaeyoung rho a, liisa kuhnspearing b, peter zioupos c a department of biomedical engineering, university of.
Pdf mechanical properties and the hierarchical structure of. Hierarchical structure mechanical properties biomimetic mechanism abstract natural selection and evolution develop a huge amount of biological materials in different environments e. Therefore, porous scaffolds with hierarchical structure have been proposed to mimic the mechanical behavior of bone 3. Hierarchical structure and mechanical properties of nacre. Characterization of the effects of xray irradiation on the hierarchical structure and mechanical properties of human cortical bone. Effect of the nanomicroscale structure of biomaterial.
Hierarchical auxetic mechanical metamaterials scientific. Nanoscale replication of the hierarchical nanoapatite assembly within the collagen. Its excellent mechanical properties are related to its hierarchical structures and precise organization of the inorganic and organic phases at the nanoscale. It is now time to bring these two aspects of skeletal tissue mechanics together. Therefore, further investigations of mechanical properties at the materials level, in addition to the studies at the structural level are needed to fill the gap in our present knowledge and to achieve a complete understanding of the mechanical properties of bone. In addition, we request that the constitutive formulation is fully threedimensional and consistent with both mechanical and mathematical requirements, applicable for arbitrary geometries and suitable for use within the context of. Bone, as a mineralized composite of inorganic mostly carbonated hydroxyapatite and organic mainly type i collagen phases, possesses a unique combination of remarkable strength and toughness. Its excellent mechanical properties are related to its hierarchical structures and precise organization of the inorganic and organic phases at. Numerous progresses have been made in the last two decades. Hierarchical structures of bone and bioinspired bone tissue. Mar 14, 2009 whole bone properties which in the end is what we should be interested in, presumably will develop quickly when fea becomes increasingly rapid as computers intensify in power, particularly when paired with an improved understanding of the mechanical properties of little subvolumes of the bones themselves. To determine the mechanical properties of a structure or, more typically, a major part of a structure, such as a beam in a bridge or the shaft of a femurengineers conduct a loaddeformation test. Hierarchical structures of bone in varied length scales rho et al.
Pdf characterization of the effects of xray irradiation. Dec 16, 2019 cell proliferation was investigated in vitro, and the surgery was conducted in a nude mouse in vivo model of long bone with cranial neural crest cells and bone marrow mesenchymal stem cells. Improving the mechanical properties of irradiation sterilized. Overall, the differences between the mechanical properties in cancellous bone are much broader than those in cortical bone and indeed may vary by a factor of 25 from bone to bone. Auxetic mechanical metamaterials are engineered systems that exhibit the unusual macroscopic property of a negative poissons ratio due to subunit structure.
Mechanical properties and the hierarchical structure of bone. The integration of structure and function for tissue engineering scaffolds is of great importance in mimicking native bone tissue. This is the basis of the theory of hierarchical structure of bone, which involves its division into different structural levels. Comparison of the structure and mechanical properties of. Bioinspired mineralization with hydroxyapatite and. Relationship of hierarchical structure to mechanical properties. Bone is also a good starting point because it illustrates the principle of hierarchical structure function that is common to all biological tissues. The term bone refers to a family of materials, all of which are built up of mineralized collagen fibrils.
1554 465 1204 277 12 1159 1264 796 1389 94 1428 1006 1659 1468 303 370 1356 17 1242 926 1620 277 1578 1402 269 10 679 457 1187 1287 916 137 1242 549 584 1465